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in healthy volunteers, the pharmacokinetics of metformin and propranolol, and metformin and ibuprofen were not affected when coadministered in single-dose interaction studies.

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Because metformin increases blood lactate levels, metformin-associated lactic acidosis mala is a rare yet life-threatening adverse effect, occurring in less than 10 people per every 100,000 users per year, according to a report in the february 2016 issue of metabolism.

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